Endocrine Abstracts

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease with incidence of 1–2 adults per milion/year. Pituitary function is affected in 30% of cases presenting almost always with diabetes insipidus. Other deficiencies such as GH, FSH+LH, TSH and ACTH follow. Erdheim–Chester disease is a rare Non-LCH described in several hundreds of cases in the world so far, with the pituitary function involvement in similar frequency as in LCH.Case...

Androgen secreting adrenal tumor is a rare cause of androgen excess in women. There are only few case-reports of androgen producing adenoma in a patient with congenital adrenal hyperplasia.Our patient, 61 year old woman was referred to our department for progressive hirsutism and androgenic alopecia. She did not mention neither excessive facial hair growth nor balding until age of 59 when rapidly progressive balding and overt hirsutism started. She has h...

Introduction: A key feature of a benign adrenal tumor is its hormonal production. It is reflected by serum steroid levels. A tumoral tissue steroid content is not commonly measured.Methods: A steroid metabolome comprising of 65 steroids was measured in four samples from each of two patients using GC-MS in serum before and after 1mg dexamethasone test, in the tumoral tissue and in the adrenal tissue of two female patients with adrenal adenomas. The first ...

Introduction: Gas chromatography tandem mass spectrometry (GC-MS/MS) quantitatively detects a large number of steroids at one time in a single serum sample. Most studies of subclinical hypercortisolism in adrenal incidentalomas have focused on detection of a few steroids like cortisol, DHEA/S, androstenedione, testosterone. We used GC-MS/MS to quantify 91 steroids in patients with adrenal incidentalomas to search for the most reliable marker of subclinical hypercortisolism.</p...

Introduction: Hyponatremia is one of the possible complications of pituitary surgery. Mild, asymptomatic hyponatremia can be managed with fluid restriction and oral supplementation, however more profound hyponatremia, especially when symptomatic, can be a reason for hospital readmission and often needs to be treated with saline infusion in ICU.Aims: To estimate prevalence of hyponatremia and provide clinical characteristics in the cohort of patients who ...

Introduction: Salivary cortisol measurement, representing free cortisol, seems to be a promissing alternative method to serum cortisol. Besides its use in the diagnostics of hypercortisolism, it could be of help in evaluation of adrenocortical reserve. It might be useful especially in patients on estrogen replacement, which modulates transcortin and hence total cortisol levels.Aims: Compare the reliability of salivary vs. serum cortisol assessment during...

Certain degree of hypopituitarism has been revealed in a significant number of patients who suffered traumatic brain injuries or subarachnoid hemorrhage. Microhemorrhages, necrosis, tissue infarcts and vasoconstriction are reported as mechanism of hypothalamo-pituitary dysfunction. Assessment of hypothalamo-pituitary endocrine functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo-pituitary unit can be expected (he...

Background: Primary hyperparathyroidism can occur at any age, the typical patient is a postmenopausal woman, primary hyperparathyroidsim is found rare by pregnant women. The maternal symptoms are similar to the symptoms by postmenopausal women.Materials and methods: Among the years 2000-2022 we have performed 3459 operations (including 6,6% reoperations) with diagnosis of hyperparathyroidism, there were six women, who underwent parathyroidectomy during p...

ACTH test is widely accepted as diagnostic tool in suspicion on peripheral as well as on central hypocorticism. The optimal dose of tetracosactide for determination of hypocorticism is still matter of debate. The 250 μg as a standard dose of tetracosactide has been approved for diagnosis of congenital adrenal hyperplasia (CAH) many years ago. Moreover, current limited availability of tetracosactide and its increased financial cost on the market raised the question whether...

The aim of the study was a detailed analysis and a comparison of hypothalamic–pituitary–adrenal axis tests and cortisol metabolites analysis during these tests. This procedure might enable to design new diagnosis algorithms of hypocorticalism and normal levels for salivary cortisol estimation for early diagnostic of patients with hypothalamic–pituitary–adrenal axis disorder as well as to give us a possibility to reveal adrenal disorder in patients on estrog...